Lamellarins isolated from oceanic mollusc are a kind of pyrrole hexacyclic alkaloids.Not only have lamellarins an interesting structural feature,but also exhibit a wide various of significant biological activities.The open-chain lamellarins have the same structure as lamellarin which shown potent cytotoxicity cytotoxic potential.ethyl 1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-2-(2,4,5-trimethoxyphenyl)pyrroloisoquinoline-3-carboxylate as a new compound and an inter mediate for synthesis of lamellarin was prepared via acylation and esterification in one pot after reaction of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline and 2-bromo-1-(2,4,5-trimethoxyphenyl)ethanone.The products were identified by means of IR,UV,NMR and MS measurement.
