As a creative and effective teaching method adopted by many countries, cooperative learning is one of the most widespread and fruitful areas in modern education theory. With the introduction of the concept of cooperative learning among College oral English teaching, students could undergo all-round training in English proficiency, cooperative ability, self-learning ability and sense of competition. This paper mainly focuses on how to make full use of cooperative leaning in College oral English teaching, and tries to verify that cooperative leaning is a practical and effective teaching mode which could enhance the College oral English classroom teaching quality.