Laboratory animal is the animal with artificial feeding in the certain conditions, having the particular biological characteristics and for scientific research. They are indispensable props of life science and have made great contributions and sacrifices for human health and development. Laboratory animal science is an important branch of the life science, including laboratory animal and animal experiment. Along with development of mankind society, economy and civilization, now the realm of laboratory animal science is confronted with the problems of animal welfare and animal ethics. The animal protectionism inevitably conflict with the laboratory animal science in the certain way. People protect the wild animals first, then protect the artificially fed animal. Also people protect pets first and then protect the laboratory animals. Now it is popularization of protecting the wild and petted animals. It makes people hard to accept the reality of the experiments with animals. But life science especially biomedicine can’t make great progress without the laboratory animals. The difference of culture and notion between different countries and different regions causes the difference in the humanism attitude to animal protection. There is a saying in China, “When mouse run on the street, everyone will be shout to beat it". But the western people create the fine image of a Mickey Mouse. The pet is one of the family members. Now maltreating animal is the moral and law problem in some developed countries. Ethics is the societal standard of human behavior. In our country, the main ethic problems in laboratory animal science lie below: relative rules and laws are absent, while no established restriction or punishment could be found to restrict those actions such as slaughtering laboratory animals. Several technical operations going against laboratory animal ethics still exist. The emotional conflicts between animal feeder and animal experimenter are not be relaxed. Since recent more than ten years, ethic research has achi