Objective With the development of science of acupuncture and moxibustion, people have, in the knowledge of "deqi", developed from subjective level to the quantitative level, and discovered many factors influencing the "deqi" of acupuncture. In this report, the relationship between "deqi" and these factors was explored in terms of different acupuncture methods and quantity and depth of stimulus. Methods Ancient literature about "deqi", as well as related literature for clinical and basic research on "deqi" in recent 10 years were systematically collected. Results (1) Cerebral functional imaging technology and the scale of "deqi" were the most common quantitative indexes for "deqi" in recent 10 years. (2) There were many factors influencing "deqi" in acupuncture, which involved personal physiological status, nature of disease, anatomical features under the acupoint, different acupuncture methods, quantity and depth of stimulus, etc. Different acupuncture methods, quantity and depth of stimulus would bring different influences on and mechanisms of "deqi". Conclusion (1) "Deqi" is not equal to needling sensation; (2) recessive needling sensation should be re-recognized; (3) the sensation of doctor should be paid attention; (4) The meaning of "deqi" should be re-defined and re-understood.