To investigate the effects and to elucidate the mechanism of Chinese herbs Recipe(consisting of Rhizoma Atractylodis Macrocephalae, Radix Salviae Simplicifoliae, Fructus Aurantii, et al) on antagonizing alcoholic liver injury from the pathological relationship between alcoholic liver injury, gut permeability and endotoxin leakage. The SD rats were fed the Lieber- Decarli liquid alcohol die(t35% of calories from alcohol)to deveclp the alcoholic liver injury model. 42 male SD rats were divided into 4 groups:normal group(n=6),no- alcohol liquid diet group in which alcohol was replaced with carbohydrates(Control group, n=12), alcohol liquid diet group(alcohol group, n=12) and alcohol liquid eiet with Chinese herbs group(herbs group, n=12). Starting from the third week, the rats were fed distilled water, no- alcohol liquid diet, alcohol liquid diet or alcoholic liquid diet with Chinese herbs by intragastric infusion for 6 weeks. Then the rats were fast for 5 h. After that, each group received 10 mg/kg of endotoxin(lipidopolysacchride, LPS)by intragastric infusion. 3.5 hours later, the blood from portal vein and vena cava was harvested and liver biopsy was performed to analyze:1. The histopathological change in small intestine (HE staining and electron microscopic observation); 2. The histopathological change in liver(HE staining, oil red O staining); 3. The TG and r- GT activities in liver and the ALT, AST activities in serum; 4. The plasma endotoxin level in portal vein blood; 5. The protein expressions(on Wetern blot) of P- I k B and TNF- a in liver.Results: that It is 1.Fatty degeneration was seen in over 1/3 of the heptocytes in the alcohol group. The liver TG level in this group was about 7.3 times higher than that in the normal group and 4.9 times higher than that in the control group. In addition, the serum ALT, AST activities as well as liver r- GT activity in the alcohol group were significantly elevated than those in the normal and control group. Observation under electron microscopy revaled swelling, degene
