Purpose:To evaluate the antiemetic efficacy and safety of domestic granisetron injection. Methods:We compared it with Metoclopramidum injection or imported Granisetron injection in 106 patients with cancer using the method of self crossover study. Results:It is shown that (1) the domestic and imported Granisetron had similar antiemitic efficacy (86.8% V 86.6%) and side effective rate (23.5% V 29.4%);(2) the effective rate of domestic Granisetron (86.8%) was significantly higher than that of Metoclopramidum (50.0%, P <0 001), and there was no significant difference in Metoclopramidum (50.0%, P <0 001),and there was no significant difference in side effect rates between Granisetron and Metoclopramidium.Conclusions:The domestic Granisetron injection is an effective and safe antiemetic drug.
