为了研究甘草对氟苯尼考药动学的影响,试验以三黄鸡为试验动物,分为空白对照组、甘草酸组和甘草提取液组,分别灌服生理盐水、甘草酸和甘草提取液(按体重2 m L/kg),每天1次,连续灌服7 d,然后各组灌服氟苯尼考并在规定时间点采样,利用高效液相色谱仪测定血药浓度后使用3P97软件进行分析。结果表明:甘草酸能显著降低氟苯尼考的吸收半衰期(t1/2Ka)、达峰时间(Tpeak);甘草提取液能显著降低氟苯尼考吸收半衰期、达峰时间、消除半衰期(t1/2Ke)、药时曲线下面积(AUC)。说明连续灌服甘草酸7 d可促进氟苯尼考在三黄鸡体内的吸收,而甘草提取液可显著加快氟苯尼考的吸收与排泄。
[Objective] The research aimed to explore the effects of Chinese herb additive on milk yield and anti-heat stress ability of Holstein cow.[Method] 36 Holstein cows with similar birth order and milk yield were equally and randomly divided into 3 groups which were control group, Chinese medicine Ⅰ group and Chinese medicine Ⅱ group. In control group, cows were fed with basic feed, while in Chinese medicine Ⅰ group, cows were fed with basic feed containing 4% compound Chinese herb additive and in Chinese medicine Ⅱ group, cows were fed with basic feed containing 3% compound Chinese herb additive.All cows in the 3 groups were analyzed comparatively.[Result] Adding some compound Chinese herb additive into basic feed would increase milk yield and anti-heat stress ability of Holstein cow,besides,it also could decrease cow diseases such as cow mastitis.Chinese medicine Ⅰ would generate the highest economic benefit of practical production.[Conclusion] Adding Chinese herb additive into basic feed is an effective way for reliefing heat stress and increasing milk yield.
