目的:探讨老年患者胃液中TNF-α,CA19-9和CEA联合检测对胃癌的诊断价值.方法:采用放射免疫技术测定42例胃癌和61例良性胃病老年患者胃液中TNF-α,CA19-9和CEA浓度.结果:胃癌组胃液中TNF-α,CA19-9和CEA的浓度显著高于良性胃病组(8.96±2.10 mg/L vs 4.92±1.24.5.66±1.25 mg/L;59.47±10.58 IU/L vs 36.89±11.23.38.73±9.23 IU/L; 31.68±5.58 mg/L vs 1'.55±3.82,19.42±5.19 mg/L,均P<0.001);胃癌组联合检测胃液中TNF-α,CA19-9和CEA,其敏感度和特异度分别97.4%,89.3%,均明显高于单项指标的敏感度和特异度.结论:联合检测胃液中TNF-α,CA19-9和CEA能有助于提高胃癌的诊断.