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郑清华

作品数:3 被引量:20H指数:3
供职机构:三峡大学更多>>
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针刺治疗糖尿病胃轻瘫的疗效及机制研究被引量:4
2018年
糖尿病胃轻瘫(DGP)是糖尿病常见的慢性并发症之一,不仅降低患者生活质量,而且影响血糖水平。目前,针对DGP的治疗主要以胃肠动力药和止吐药的使用为主,但其临床疗效并不理想,且撤药后病情容易复发。近年来,针刺因副作用小,疗效显著、持久,而被广泛应用于DGP的临床治疗。本研究就针刺治疗DGP的可能作用机制、临床疗效及存在的问题进行综述,以期为临床推广应用针刺治疗DGP提供理论依据。
梅清鲜杨松柏郑清华王金凤梅志刚
关键词:针刺治疗糖尿病胃轻瘫
Meta analysis on acupuncture for postpartum depression被引量:12
2017年
Objective To evaluate the clinical efficacy of acupuncture in treatment of postpartum depression. Methods Pubmed database and Embase database were retrieved online in English, and China National Knowledge Internet (CNKI), China Biology Medicine disc (CBM), VIP database and Wanfang Data were retrieved in Chinese. Literature in recent 10 years relating to clinical randomized controlled trials of acupuncture in treatment of postpartum depression were collected, and Meta analysis was performed by adopting RevMan5.3. Results Fourteen articles were included in the study in total; it was shown from HAMD result that after combination, WMD=-2.27, 95%CI (-2.55, 0.01); according to Z-test, Z=2.95, P=0.05, and the difference in efficacy between treatment group and control group was statistically significant. It was shown from EPDS result that after combination, WMD=-0.53, 95%CI (-0.92, -0.03); according to Z-test, Z=2.08, P〈0.05, and the difference in efficacy between treatment group and control group was statistically significant. During the analysis taking estradiol as standard, it was shown from the result that after combination, WMD=63.99, 95%CI (13.39, 114.60); according to Z-test, Z=2.48, P〈0.05, and the difference in efficacy between treatment group and control group had remarkably statistical significance. During the analysis taking effective rate as standard, it was shown from the result that after combination, OR=3.15, 95%CI (2.19, 4.55); according to Z-test, Z=6.14, P〈0.05, and the difference in efficacy between treatment group and control group had remarkably statistical significance. Conclusion Acupuncture treatment for postpartum depression is effective, but more clinical randomized controlled trials with high quality and large sample size are still needed to verify the result.
王金凤谭凌菁梅清鲜郑清华杨松柏梅志刚
关键词:ACUPUNCTURE
脂氧素A4与2型糖尿病早期肾脏疾病相关性观察被引量:4
2018年
目的探讨T2DM患者血清脂氧素A4(LXA4)与早期糖尿病肾脏疾病(EDN)的相关性。方法选取新诊断40例单纯T2DM患者、38例EDN患者及40名健康体检者(NC组)。ELISA测定空腹血清LXA4水平。结果 NC组、T2DM组、EDN组血清LXA4水平依次降低[(551.48±52.71)vs(502.63±48.57)vs(464.78±42.56)pg/ml,(P<0.05或P<0.01)];血清LXA4水平与血红素加氧酶1(HO-1)呈正相关(r=0.512,P<0.05),与胰岛素抵抗指数(HOMA-IR)、FIns、FPG、HbA_1c、血管内皮生长因子(VEGF)、UACR、病程、转化生长因子β1(TGF-β1)、白细胞介素6(IL-6)、BUN、Scr呈负相关(r=-0.612、-0.512、-0.532、-0.552、-0.528、-0.598、-0.596、-0.603、-0.617、-0.598、-0.550,P<0.05或P<0.01);Logistic回归分析显示,HbA_1c、LXA4是EDN的独立影响因素。结论 EDN患者血清LXA4水平降低,在EDN中发挥重要作用。
徐峰韩庆龙郭巍覃佐涛郑清华朱国龙张高锋
关键词:脂氧素A4糖尿病肾脏疾病
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