Abstract: With a determinate danger zone and evacuation demand caused by an emergency, an optimization method for the evacuation zone with network reconfiguration based on dynamic simulation is proposed. The method contains three modules. First, the network in the evacuation zone is optimized by a model with the integrated strategy of lane reversal and intersection conflict elimination. Secondly, the dynamic evacuation simulation model based on the cell transmission model is applied to simulate the dynamic propagation process of evacuated vehicles in the network in the evacuation zone. The evacuation time for all evacuated vehicles leaving the danger zone is obtained and the setting of the current evacuation zone is fed back. Thirdly, the arrival distributions of evacuated vehicles at critical intersections of the evacuation zone are also obtained to estimate the delay at critical intersection to determine whether the intersection should be taken as the critical intersection in the next iteration. The evacuation zone is expanded gradually through iteration, and the reasonable evacuation zone and the optimal evacuation network is confirmed. Based on the survey of the parking lot and urban street network around Nanjing Olympic Sports Center, the models and the iterative algorithm were applied to obtain the optimal plan of the evacuation zone with network reconfiguration in an evacuation situation to verify the validity of the proposed method.