Objective To observe the clinical efficacy of treating simple pediatric diarrhea by chiropractic therapy. Methods Forty-two cases of simple diarrhea were treated with chiropractic therapy along the points from Guiwei (龟尾) to Dazhui (大椎 GV 14), once a day, with a total of three times. The clinical efficacy was observed. Results Thirty-eight cases were cured (90.5%) and 4 cases were improved (9.5%) with the total effective rate of 100%. Conclusion The chiropractic therapy has good efficacy in treating simple pediatric diarrhea and worthy of clinical promotion.