Objective To compare the therapeutic effect of catgut embedding combined with diet plus exercise with that of diet plus exercise in treating simple obesity complicated with abnormal blood fat. Methods A prescription of diet plus exercise was given to the patients in a control group, and catgut embedding was added to the prescription in a treatment group. It was given once every 15 days for the 1st three treatments, and once every month for the 2^nd three treatments. Six treatments constituted a therapeutic course. Body weight and blood fat were measured before and half a year since treatment. Results After treatment, BMI, TO, TG and LDL were very significantly improved in the treatment group (P〈0.01), and BMI and TG were very significantly (P〈0.01) and TO and LDL were significantly (P〈0.05) improved in the control group. HDL was not obviously improved in both groups (P〉0.05). The improvement of TO, TG and LDL in the treatment group was significantly more than that in the control group (P〈0.01), but no difference in improvement of BMI and HDL was found between the two groups (P〉0.05). Conclusion The therapy of diet plus exercise was effective in body weight reduction and lowering blood fat in patients with simple obesity complicated with abnormal blood fat, and catgut embedding used in combination was even better in lowering blood fat.