We live in an uncertain world. We pursue science, institution and life with certainty just because of the uncertainty. The reasons of uncertainty exist in cognition, practice, and specialties of subject who unifies practice and cognition from the perspective of subject. Practice is the most fundamental and important reason not eliminated among the factors. Uncertainty without eradication makes the social system energetic, provides space for the irrational factors and invigorates the subjectivity, which is the premise to the existence of many valuable things. Therefore, uncertainty is not just negative “being”, but the aspiring actions that is the one and only reasonable choice. When it comes to act, taking uncertainty as the starting point can help us keep level-headed.