Four pyridazinone gluosodes 4 were synthesized by Koenig′s Knorr reaction of 6 (4 halophenyl) 3( 2H ) pyridazinone silver salt 2 with bromoacetylglucose 3.Treatment of 4 with dry ammonia at 0～-5℃ effected a removal of the acetyl protecting groups to yield compounds 5.When the substituent on the benaene ring was F or Cl ,O glucoside was synthesized principally.However,when the substituent was Br or I ,N glucoside was mainly obtained.Their structures were confirmed by 1H NMR,IR and elemental analysis.
