[Objective] This study aimed to investigate the dynamic changes of vegetation cover and its prediction method. [Method] The NDVl was used as data source to perform the spatial overlay analysis on the vegetation coverage changes of the study area in different time period under the GIS platform, with the aim to reveal the spatial distribution rules of the vegetation cover in Eastern Jilin Province during the recent 10 years. The Markov Model and Grey System G (1, 1) theory model were used to predict the vegetation cover change trend in Eastern Jilin Province. [Result] The vegetation cover increased a little, but staying stable in general. The regions with great changes were mainly around the lake and river. The prediction results of Markov Model and Grey System G (1, 1) theory model were consistent with the observed measurement. [Conclusion] This study provided referential basis for the effective protection of the vegetation coverage in mountainous forest, and important reference value for the scientific decision-making on the forest construction planning in Jilin Province as well as in China and sustainable development of social economy.