Objective:To explore the clinical significance of lung resistance protein (LRP) in ovarian epithelial tumors.Methods:The expressions of LRP and P-gp were examined by immunochemical methods in 54 ovarian epithelial carcinomas,15 borderline tumors,20 benign tumors and 18 normal ovarian tissues.The relationships among the expression of two factors and clinical pathologic features,resistance to chemotherapy and prognoses were analyzed.Results:1.The positive rates of LRP and P-gp in ovarian epithelial carcinoma were 75.9% and 38.9%,repectively.Of the five borderline tumors 4 were LRP-positive and 2 were P-gp-positive.6 benign tumors and 7 normal controls showed LRP positive,while none of the ovarian benign tumors and normal control was found P-gp expression.2.The expression of LRP was associated with presence of ascites not with age,FIGO stage,histologic type,grade,residual tumor and the size of tumor.The expression of P-gp was not associated with any clinicopathologic features;3.The response rates to chemotherapy in patents with LRP positive and LRP negative were 50.0% and 84.6%,respectively(P<0.05),while that of P-gp were 40.0% and 69.7% respectively (P<0.05).4.The prognoses of LRP positive of P-gp positive patients are poorer than those of negative patients respectively.Conclusions:LRP expression in ovarian epithelial carcionma is related to drug resistance and it is an useful prognostic factor.
