The computation of the design load on culverts in the current Chinese General Code for Design of Highway Bridges and Culverts (CGCDHBC)is primarily based on the linear earth pressure theory, which cannot accurately reflect the changes in vertical loads on trench installation culverts. So the changes in vertical earth pressure and soil arching effect in the backfill for an unsymmetrical trench installation culvert are studied based on a full scale experiment and finite element (FE) simulation. The variation laws of foundation pressure and settlement are also analyzed. Meanwhile, the influence of eccentric load induced by an unsymmetrical trench installation on the interaction of a soil- structure system is discussed. Results show that soil arch is formed when the backfill on the culvert reaches a certain height. It can relieve the earth pressure concentration on the crest of the culvert, but it is instable. The earth pressures obtained by full scale experiment and numerical simulation are greater than those calculated by the current CGCDHBC method. The eccentric load effect on the culvert has a significant influence on the stress states and deformation of the soil-structure system.