[Objective] This study was conducted to investigate the eco-geochemical characteristics of corn production area in Inner Mongolia Hetao agricultural economic zone. [Method] Corn root soils and corn samples from various parts were collected from the Inner Mongolia Hetao agricultural economic zone. Trace element contents in root soils and different parts of corn were analyzed. [Result] Most element contents in cumulated irrigated soil were relatively higher. Most elements were relatively enriched in the stems and leaves of corn. F, Mn and Co were relatively enriched in roots of corn; and N was strongly enriched in grains, and Zn and F were relatively enriched in grains. [Conclusion] It is necessary to rationally apply fertilizer in corn production area in Hetao and control the application of harmful elements in fertilizer in future.