Liposome capillary electrophoresis(LCE) provides a novel and facile approach for determining hydrophobic parameters(lgP) of organic compounds.In order to avoid the error of the migration time of liposome phase(tl) on determination,a novel technique was developed in this paper,in which the tl was obtained via non-linearity fitting with lgP values from literatures and migration time(tm) of a series of standard compounds.lgP values of the six benzene derivatives determined by this LCE method were compared with literature values and the ones obtained by directly determined tl and MEEKC.The average error between lgP values determined by two LCE methods was 0.07 logarithm units.The LCE method was simple and rapid,which can provide a new way to determine lgP of organic compounds.
