Objective To survey the exchange rate of the sodium ion and the magnesium ion in the erythrocyte of patients with the essential hypertension and the cerebral hemorrhage and the cerebral infarction and to probe the relationship with Na +/Mg 2+ ion and endotheinlin -1.Methods The erythrocyte concentration of the sodium and magnesium ion were measured by the flame assay of atomic absorption spectropholometry in 23 patients with EH and 21 patients with CH and 34 patients with CI. The maximum rates of total magnesium efflux(VTmax) and the sodium-independent magnesium efflux (VNImax) and the sodium-dependent magnesium efflux(VNDmax) were determined . The plasma endothenlin-1 was measured in all patients Results (1)There were no difference for the plasma sodium and the plasma magnesium in patients with EH and the normal control (P> 0.05). The EH cases showed significantly a lower EMC and a higher VNDmax and VTmax than normal controls (P<0.05). (2)The CH and CI cases showed significantly higher in ESC and lower EMC and faster VNDmax and VTmax than normal controls. There were the significantly negative correlated with EMC and ET and the significantly positive correlated with the EMC and the sodium ion in erythrocyte in these cases. Conclusion The rapid exchange rate of the sodium ion and the magnesium ion in erythrocyte leads the higher in sodium ion and lower magnesium ion in erythrocyte, meanwhile the ET influence these effect.
