Laminine(4) is a kind of non-protein amino acids in the kelp,which can prevent and cure hypertension.Because of its trace amount in the nature,it was always prepared by using bio-mimetic synthesis methods.And none or few of the synthetic methods of compound 4 were reported so far.In this article,with lysine(1) as the starting material,compound 4 was prepared with bio-mimetic synthesis method,with a yield of 37.6% and a purity of 97.2%.The structure of compound 4 was determined via HPLC,IR,MS,1H NMR,13C NMR and element analysis,and some of its physical and chemical properties were also studied.The results show that compound 4 is white crystalloid and has no smell,the quasi-molecular ion peak of compound 4 is m/z 207.1,and chemical shift δ 3.63(s,9H),the features at 2945, 2863 and 1480 cm-1 in IR spectrum all show that ε-amino group of compound 4 is fully alkylated.This method could get pure laminine with simple operations,and it could be considered as a green technology with great industrial profits and notable ecological values.
