In allusion to the characteristics of the open complex giant system, an open multilevel hierarchic intelligent control system is established for the eco-industrial system. With the idea of the open engineering system, using the hall for workshop of metasynthetic engineering (HWME), intelligent control techniques, the expert system and the design of experiments are integrated within the framework of the nonlinear multiobjective decision support system to develop a robust, top-level design specification so as to make the system have the quality of adaptive control, self-organizing, self-learning and robustness. Finally, an illustrative example is given to clarify the effectiveness of the method.