[Objective] This study aimed at investigating the effect of chemical regulation on maize cultivated in different densities.[Method] By taking maize hybrids Xundan 20 and Zhongnongda 4 as materials,the effect of chemical regulation on the yield,yield component factors and plant morphology of the two hybrids planting in Northern and Northeastern China were studied,respectively.[Result] Chemical Yuhuangjin could control maize stalks,lower the plant height and the ear height,make internodes below the spike more coarse and enhance its lodging-resistance.In addition,chemical regulation could increase the optimum cultivation density by 7 500 plants/hm2 more than traditional cultivation.[Conclusion] This paper provided theoretical reference for cultivating high-yield maize.