Insufficient vocabulary has become a barrier to reading comprehension and translation in the process of ME (medical English) study to the third-year students at medical universities or colleges. The current study was designed to investigate corpus-based teaching ap-proach to enlarging students'vocabulary in the course of higher learning of ML (medical literature). The study was carried out from 2006.9 to 2008.9 among third-year medical students in our college. Students were encouraged to augment their vocabulary by active practice,intensive learning,and comprehensive learning respectively through discovering study by using self-made ME corpuses (90,000 words). In doing so,their vocabulary was enlarged by actively using the essential vocabulary,attaching more attention to the difficult technical vocabulary,and getting familiar with medical terms,which eliminated their language barrier,improved their integrated language proficiency,and developed their sense of achievement.