With wide applications of electromagnetic instruments and equipments in medical treatment, scientific re- search and national defense, and daily life items of computers, mobile telephones, and microwave ovens etc, elec- tromagnetic radiations have brought us great benefit. However, there are potential damages with electromagnetic radiations,e.g. the electromagnetic pulse (EMP), which is not ionizing radiation but can cause vibration of atoms or molecules and alter electron energy levels. It has been reported that EMP could decrease the learning and recol- lection ability of mice and rats through inducing metabolic disorder of neurotransmitter in mice brain and affect the brain wave of anesthetized rats. EMP also has some effect on immune, procreation and endocrine system of mice. The integrity of the blood-brain barrier (BBB) was detected in order to observe the effects of J005A electro- magnetic wave shielding textile (JEWST) on bio-effects of EMP. 48 BALB/c male mice were randomly divided into exposure groups and JEWST protection groups (n=6). EMP was generated from a bounded-wave simulator and transmitted into a GTEM cell in which the mice were exposed. The field intensity was 0, 100, 200 and 400 kV m-1, respectively. The integrity of the BBB was determined by a quantitative measurement of Evans blue (EB) dye. The quantity of penetrated EB in brains of the mice increased obviously after exposure to 100, 200and 400 kV m-1 EMP, compared with the control groups (p<0.0 1). In JEWST prevention groups, the quantity of penetrated EB was significantly decreased after exposure compared with the exposure groups. EMPs of 100, 200 and 400 kV m-1 could increase the permeability of BBB in mice. The J005A electromagnetic wave shieldlng textile may prevent BBB from EMP induced BBB injury in mice.