Objective:To study the characteristics and mechanisms of language disorders in predominant periventricular lesion.Methods: 40 Patients with periventricular infarction were assessed on the Aphasia Battery in Chinese (ABC), results were analyzed to determine the relationship between neuroiconography and speech function. Results: lesion of anterial lateral ventricle led to acute mutism, limited spontaneous speech, and disorder of speech initiation. Lesion near medial lateral paraventricle led to aphemia. All these lesions are usually associated with stuttering. Conclusion: The white matter anteromedial lateral paraventricular is an important part in the automatic processes that involved in speech production. Different lesions of these regions may result in different language disorders.