Based on the prediction results of over twenty new climate models provided by Intergovernmental Panel on Climate Change(IPCC) ,the climate change trends in Yangtze-Huaihe region during 2011-2100 were analyzed under the SRES A1B scenario. The results showed that annual mean temperature in Yangtze-Huaihe region would go up gradually under the background of global warming,and temperature increase rose from southeast to northwest,while annual average temperature would increase by 3.3 ℃ in the late 20th century. Meanwhile,annual average precipitation would rise persistently,and precipitation increase would go up with the increase of latitude and the lapse of time,being obviously strengthened after 2041.