The supported bilayer lipid membrane(s-BLM) was served as a biomembrane model. The interaction between sodium cholate(NaC) and s-BLM was investigated by cyclic voltammetry and alternating current(AC) impedance spectroscopy. The following conclusions were obtained: NaC can decrease the orderliness of lecithin molecule arrangement and induce pores or defects on s-BLM and the interaction between them depends on time, concentration and cholesterol. In addition, the defective s-BLM after interaction can be self-repaired in 0.1 mol/L KCl solution, which indicates that the interaction is reversible. Moreover, a possible mechanism of the interaction was proposed finally.
