Isothermal compression tests in a wide range of temperatures (300-500 ℃) and strain rates (0.001-10 s^-1), were performed on 2099 alloy to reveal the hot deformation characteristics. In order to give a precise prediction of flow behavior, the obtained experimental data were modified by friction and temperature correction and then employed to derive the constitutive modeling. The effects of the temperature and strain rate on hot deformation behavior can be expressed by Zener-Hollomon parameter including Arrhenius term. Furthermore, the influence of strain was incorporated in the constitutive analysis by considering the effect of strain on material constants (i.e. a, n, Q and A). Consequently, the flow stress curves predicted by the developed modeling show a good agreement with the corrected ones, which indicates that the developed constitutive modeling could give an accurate and precise prediction for the flow stress of 2099 alloy.