The target reliability indices of the foundation structures of sea-crossing bridges on the serviceability limit state (SLS) are different from those of common bridges due to their different surroundings. Consequently, three levels of the target reliability indices, which are 1.5, 2. 0 and 2. 3, respectively, for those structures on the SLS are suggested based on the Joint Committee on Structural Safety (JCSS) model code, and a new method of calibrating factors of live loads, which is based on the contribution ratio of tensile stresses of reinforcing bars produced by various loads to the maximum crack width of concrete, is proposed. Finally, the calibration of the reliability-based factors of the frequent value and the quasi-permanent value of live loads is conducted by the Joint Committee (JC) method through an actual design, and the indices are proved to be reasonable and the new method is proved to be feasible.