多耐药非发酵革兰阴性菌已成为重症监护室院内感染的重要病原菌,近年来其检出率在全球有逐年上升的趋势,对其危险因素和治疗进展的探讨具有重要意义.入院前有抗生素使用史、反复插管、最初不恰当抗生素治疗即病原菌对所用抗菌药物不敏感、重症监护室住院时间延长等是耐药菌院内感染常见的危险因素.关于耐药菌院内感染的治疗,采用早期适当联合用药原则,控制感染. Progress on risk factors and treatment of nosocomial infection of resistant nonfermenting gram-negative bacteria in intensive care unit QI Chun-yan （Department of Respiratory Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China） YAN Xi-xin（Department of Respiratory Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China） Abstract：Multidrug resistant nonfermenting gram-negative bacteria have become important nosocomial pathogens in intensive care unit. In recent years,the incidence in the world has increased year after year,it is significant to discuss the risk factors and progress of treatment. The common risk factors of nosocomial infection of drug-resistant bacteria are antibiotic usc before admission, repeated intubation,initial inappropriate antibiotic treatment （pathogens are not sensitive to antibiotics）,and extended length of stay in intensive care unit. The principle of treatment about nosocomial infection of drug-resistant bacteria is early and appropriate drug combination to control infection.Keywords：Intensive care unit; Multidrug resistance; Nonfermenting gram-negative bacteria;Nosocomial
