Objective:To evaluate the effect of Shen Rou Yang Zhen Decoction on blood rheology of the patients with Piyinxu. Methods:30 cases of patients with Piyinxu were treated with Shen Rou Yang Zhen Decoction.The blood rheology was detected before and after treatment. Results:30 cases of patients with Piyinxu were treated for one course of treatment resulting in obvious efficiency in 9 cases(30 % ), efficiency in 19 cases(63.33 % ), inefficiency in 2 cases (6.67%). The overall effective rate was 93.33%. The indexes of blood rheology including blood viscosity and plasma viscosity were significantly reduced (P < 0.01). Conclusions: Shen Rou Yang Zhen Decoction can reduce the blood viscosity and improve the blood rheology in patients with Piyinxu.