目的研究烫伤灵的药理作用。方法采用巴豆油致炎模型,用烫伤灵高、低剂量皮下注射,30 m in后处死取小鼠腹腔液测定其对毛细血管通透性的影响;同时采用扭体法、热板法,考察镇痛作用。结果烫伤灵高剂量组与獾油组均有较强的抗炎作用(P<0.01);烫伤灵与空白组比较均有明显的镇痛作用(P<0.01)。结论烫伤灵对动物体表深度烫伤有较好的治疗作用,具有明显的镇痛、抗炎作用。
Aim To study the chemical constituents from the roots and rhizomes of Clematis hexapetala Pall.. Methods The components were isolated by means of solvent extraction, repeated chromatography with silica gel, sephadex LH-20 and prep-HPLC. The structures were determined by spectrum analysis. Results Twelve flavonoids were isolated and their structures were identified as 3, 5, 6, 7, 8, 3＇, 4＇-heptamethoxyflavone （1）, nobiletin （2）, liquiritigenin （3）, hesperetin （4）, naringenin （5）, liquiritigen-7-O-β-D-glucopyranoside （6）, 5,7, 4＇ -trihydroxy-3＇- methoxyflavanone -7-O-α-L-rhamnopyranosyl （ 1→6 ） -β-D-glucopyranoside （7）, 6-hydroxybiochain A （ 8）, formononetin （9）, daidzein （10）, genistein （11）, and tectoridin （12）. Conclusion All the said compounds were isolated from the plant for the first time.
