An approach based on equivalent mechanics theory and computational fluid dynamics (CFD) technology is proposed to estimate dynamical influence of propellant sloshing on the spacecraft. A mechanical model is estab- lished by using CFD technique and packed as a "sloshing" block used in spacecraft guidance navigation and control (GNC) simulation loop. The block takes motion characteristics of the spacecraft as inputs and outputs of pertur- bative force and torques induced by propellant sloshing, thus it is more convenient for analyzing coupling effect between propellant sloshing dynamic and spacecraft GNC than using CFD packages. An example demonstrates the accuracy and the superiority of the approach. Then, the deducing process is applied to practical cases, and simulation results validate that the proposed approach is efficient for identifying the problems induced by sloshing and evaluating effectiveness of several typical designs of sloshing suppression.