国内资料报道脑转移瘤占颅内肿瘤的3.5%～10%[1],国外报道占23.3%[2].近年来随着CT、MRI等检查手段的发展,检出率明显提高;另外一方面,随着医疗整体水平的提高,癌症患者的生存时间延长,因此脑转移瘤临床发病率有逐年上升的趋势,据美国国家癌症研究所[3](National Cancer Institute,NCI)2000年资料,癌症患者有20%～40%最终发生脑转移.本文对1993年3月至2002年3月收住我院的238例脑转移瘤病人的资料进行综合分析如下.
Slit2/Robo1 is a conserved ligand-receptor system,which greatly affects the distribution,migration,axon guidance and branching of neuron cells.Slit2 and its transmembrane receptor Robo1 have different distribution patterns in gliomas.The expression of Slit2 is at very low levels in pilocytic astrocytoma,fibrillary astrocytoma and glioblastoma,while Robo1 is highly expressed in different grades of gliomas at both mRNA and protein levels.Acquisition of insidious invasiveness by malignant glioma cells involves multiple genetic alterations in signaling pathways.Although the specific mechanisms of tumor-suppressive effect of Slit2/Robo1 have not been elucidated,it has been proved that Slit2/Robo1 signaling inhibits glioma cellmigration and invasion by inactivation of Cdc42-GTP.With the research development on the molecular mechanisms of Slit2/Robo1 signaling in glioma invasion and migration,Slit2/Robo1 signaling may become a potential target for glioma prevention and treatment.
