Objective To study the clinicopathological fe atures of the multiple primary cance r in Chinese hereditary nonpolyposis colorectal cancer(HNPCC).Methods Thirty-two kindreds with HNPCC were registered and followed up.Clinical data were analyzed.Results Among 91cases of 32HNPCC kindreds,10cases from 9kindreds developed multiple metachronous prim ary cancers and no synchronous cancers were found.Eight cases of ab ove 10cases were from typical HNPCC f amilies.The initial cancer presented as colorectal cancer in 9p atients.The second tumor presented as colonic cancer in 3patients,hepatic cancer.oophoroma and endom etrial carcinoma in 2patients respectively,and cereglioma in one patient.The second tumor occurred a fter 60～108mouths(mean 68mouths).Conclusions The morbidity of the multiple primary cancer of Chi nese HNPCC kindreds increases.HNPC C patients should be followed up strictly in order to discover multip le primary cancer earlier and get better outcome.
