Objective: To understand the effects of comprehensive intervention on mental health problems of students in boarding high school. Methods: Individual psychological counseling, group psychological counseling and biofeedback therapy were used to intervene the mental health problems of high school students.Results: Main disorders in comprehensive intervening were learning problems, interpersonal relationship problem, sleep disorder and examination anxiety. After intervention, there were significant improvement in self-concept,and family environment, but there were no improvement in intelligence and emotional states. Conclusion:Comprehensive intervention was effective for resolving the mental health problems in boarding high school.