Electrical remodeling in atrial fibrillation(AF)is considered to beget AF.However,in AF,decreased expressions of introverted ion currents INa and ICa channel proteins are corresponding to the induced increase of ion concentration in cells to maintain the membranes’polarity;ITo is phase 1 instantaneous extraverted K+current,IKur is the important extraverted K+current in phases 1 and 2,IKr,IKs are the main extraverted current in phase 2,and the ion channel proteins of them are down-regulated in AF to prolong atrial effective refractory period(AERP),which is disadvantageous to reentry;IK1,IKAch,IKATP work in phase 3,and their up-regulated channel proteins amplify myocardium diastolic potential,lower the myocardium excitability and reduce the ectopic excitement.Therefore,in AF,atrial electrical remodeling is not to beget AF,but to restore its physiological function.AF begets AF in that it can cause atrial structural remodeling,and the structural remodeling facilitates AF initiation and perpetuation.The interaction eventually aggravates atrial muscle injury and induces myocardial electrical disorder.
