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刘宁

作品数:4 被引量:8H指数:1
供职机构:中国科学院昆明动物研究所更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划更多>>
相关领域:医药卫生生物学更多>>

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Auditory evoked potentials recorded in monkeys with hallucinatory-like behaviors induced by bromocriptine
2006年
Objective Bromocriptine and other dopamine D2 receptor agonists can affect a range of behaviors in nonhuman primates, particularly those behaviors associated with motor and mental function, such as suppressant behaviors and hallucinatory-like behaviors in monkeys. Besides bromocriptine, the dysfunction of the rapid eye movement sleep (REM) mechanism may also contribute to hallucinations. Dissociation of wakefulness, REM, and non-REM (NREM) can cause a series of psychotic symptoms. Methods In present study, we simultaneously recorded auditory evoked potentials (AEP) from five cerebral regions in monkeys during normal and psychotomimetic states to investigate and compare state-dependent changes in AEE Results Phase reversal of peak-to-baseline amplitude of 250 ms component (PBA250) in dorsolateral prefrontal cortex was common characteristic of hallucinatory-like and REM, and that hallucinatory-like and REM shared the equivalent modulatory orderliness of the PBA250 in dorsolateral prefrontal cortex. This result suggests that hallucinatory-like and REM share an equivalent electrophysiological modulatory in dorsolateral prefrontal cortex. Conclusion Our results reveal that emergence of the N250 in dorsolateral prefrontal cortex is an exclusive marker that may help to discern whether hallucinatory-like behaviors is exhibited, which suggests that dorsolateral prefrontal cortex may be the most pivotal region for exhibition of hallucinatory-like behaviors.
陈绍琦刘宁郑佳威齐华肖壮伟
关键词:BROMOCRIPTINE
慢性吗啡给予、戒断及再给药过程中大鼠海马感觉门控的动态变化被引量:6
2007年
药物成瘾被认为是药物长期作用于脑而产生的一种慢性复吸性脑疾病,长期反复的药物(如吗啡)滥用会导致一系列严重后果,如药物依赖、药物耐受、强迫性药物寻求等。本实验利用条件化位置偏好(conditioned place preference,CPP)模型来检测大鼠对吗啡依赖和心理渴求等过程;采用双声刺激听觉诱发电位来研究大鼠在慢性吗啡给予、戒断以及再给药过程中海马感觉门控(N40)的动态变化。吗啡组大鼠注射吗啡(10mg/kg,i.p.)12d,经历第一次戒断12d,再次注射吗啡(2.5mg/kg,i.P.)1d,之后经历第二次戒断2d;对照组大鼠注射同体积生理盐水,其余实验条件与吗啡组相同。CPP实验表明,这种药物给予方法促使大鼠对吗啡产生药物依赖和心理渴求。双声刺激诱发电位实验表明,吗啡组大鼠在吗啡给予期间海马感觉门控受到损伤;第一次戒断期的第1~2天海马感觉门控能力减弱,第3天增强,第4~12天逐渐恢复到正常水平;再次给予吗啡后海马感觉门控能力与对照组相比显著降低,并且随后2d的戒断期内海马感觉门控能力也一直保持较低水平,表明再次给药使大鼠海马感觉门控对吗啡更加敏感化。结果提示,长期反复的吗啡给予及再给药干扰了海马的感觉门控能力,吗啡成瘾对大脑可能产生长期影响。
杨光刘小粉刘宁张洁郑佳威孙华英孙华英张文德
关键词:听觉诱发电位感觉门控吗啡海马
A Training Program for Visual Discrimination Tasks in Monkeys被引量:1
2006年
Go/NoGo tasks are a useful behavioral model in the study of cognitive neurosciences. The present developmental study is aimed at establishing a developmental protocol of Go/NoGo visual-discrimination tasks to investigate more cognitive process. We used two rhesus monkeys to test our procedures. Our results suggested that the monkeys quickly learned Go/NoGo visual-discrimination tasks, and performed NoGo tasks better and easier than Go tasks. Using this visual-discrimination task, we can easily study related cognitive neurosciences.
谭华孟志强刘宁马原野Fraser A.W.Wilson
关键词:MONKEY
阿片类物质滥用对认知和情绪的影响及其机制的研究
药物滥用是一种慢性、复发性脑疾病,有着极其复杂的机理。其核心特征是强制性觅药和用药行为,即成瘾者失去了对药物寻求和使用行为的控制。大量的实验证据表明,药物滥用会导致认知功能的损伤和认知偏差,并会造成情绪的异常,这可能是药...
刘宁
关键词:药物滥用阿片类物质脑机制情绪反应
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