The variation and influence factors of yield gravity center of flue-cured tobacco in Hunan were studied in 2006-2015 by regional gravity center method and grey correlation analysis. The results showed that the yields of flue-cured tobacco in various areas in Hunan were mainly of the growing with fluctuation type. The yield gravity centers in the whole province and eastern, southern and western Hunan tobacco-growing areas overall moved in the north by west, south by west, west by south, and south by east directions, respectively; and the movements in the south-north direction were in order of eastern Hunan tobacco-growing area 〉whole province 〉western Hunan tobacco-growing area 〉southern Hunan tobacco-growing area, and the movements inthe east-west direction showed an order of eastern Hunan tobecco-growing area〉western Hunan tobacco-growing area〉whole province〉 southern Hunan tobacco-growing area. The main influence factors of the coordinates of the longitudes and the latitudes differed. The main influence factor was planting area in most cities or counties in the whole province, and was per unit area yield in a few cities or counties. It is advised to construct the "one main body and two wings" development pattern of flue-cured tobacco production in Hunan with southern Hunan tobacco-growing area as the main body and western and eastern Hunan tobacco-growing areas as the two wings.