目的:观察麻荆止咳颗粒对咳嗽变异性哮喘(CVA)模型大鼠肺组织病理形态学变化及咳嗽次数的影响,探讨麻荆止咳颗粒改善CVA气道炎症的作用及疗效。方法:将60只SPF级SD雄性大鼠按照随机数字表法分为空白组、模型组、孟鲁司特钠组和麻荆止咳颗粒低、中、高剂量组各10只。空白组不予造模,其余各组均采用卵清白蛋白(OVA)和氢氧化铝凝胶致敏并用OVA雾化激发的方法复制CVA模型大鼠。造模成功后,孟鲁司特钠组给予孟鲁司特钠溶液,麻荆止咳颗粒低、中、高剂量组分别给予麻荆止咳颗粒溶液对应药物剂量灌胃给药,空白组、模型组给予等体积蒸馏水,每天1次,连续14天。观察6组大鼠HE染色肺组织病理形态学变化及末次给药后3 min内咳嗽次数。结果:与空白组比较,模型组可见显著的气道炎症表现,末次给药后3 min咳嗽次数明显增多(P P P P > 0.05),麻荆止咳颗粒低、中、高剂量组气道炎症浸润改善情况无显著性差异(P > 0.05)。结论:麻荆止咳颗粒可减轻CVA大鼠肺组织的气道炎性损伤,减少咳嗽次数,从而减轻气道炎症,促进疾病恢复。Objective: To observe the effect of Majing Zhike Granules on the pathological morphological changes of lung tissue and the number of coughs in rats with cough variant asthma (CVA) model, and to explore the effect and efficacy of Majing Zhike Granules in improving CVA airway inflammation. Methods: Sixty SPF SD male rats were randomly divided into a blank group, a model group, a montelukast sodium group, and a low-, medium-, and high-dose Majing Zhike Granules group, 10 in each group. The blank group was not modeled, and the remaining groups were sensitized with ovalbumin (OVA) and aluminum hydroxide gel and stimulated with OVA aerosol to replicate the CVA model rats. After successful modeling, the montelukast sodium group was given montelukast sodium solution, and the low-, medium-, and high-dose Majing Zhike Granules groups wer
