Ropivacaine is pure(S-enantiomer) amino-amide local anaesthetic.Especially its better cardiotoxic profile than identical concentrations of bupivacaine has been well documented.The clear advantages of the long duration of action,and extensive margin of safety,and powerful analgesic effect and sensory-motor differential block(at lower concentrations) seen with ropivacaine relative to bupivacaine will be advantageous in certain applications.The physico-chemical properties of ropivacaine suggest that its rate of onset(related to pKa) should be similar to that of bupivacaine,and that its absolute potency(lipid solubility) and duration of effect(protein binding) should be sightly less.Ropivacaine has been introduced into clinical practice recently including infiltration anesthesia,nerve block,epidural block,spinal anesthesia, painless birth,and post-surgical analgesia.Based on available clinical data, ropivacaine appears to be as effective as bupivacaine when equal analgesic doses are
丙型肝炎病毒(hepatitis C virus,HCV)感染严重威胁人类健康和生活质量[1]。研究发现,辅助性T细胞(T helper,Th)介导免疫应答的强度和特异性可影响HCV病毒清除和感染恢复[2]。白介素-10(interleukin-10,IL-10)主要由Th2型细胞分泌,是一种重要的免疫调节细胞因子,可抑制由病毒感染引起的炎症反应[3]。