张盛
- 作品数：13 被引量：14H指数：2
- 供职机构：厦门大学附属中山医院更多>>
- 发文基金：国家自然科学基金福建省中医药重点研究室建设项目国家科技重大专项更多>>
- 相关领域：医药卫生更多>>
- DNA甲基化转移酶1/3b与肝癌临床病理特征和预后相关性研究被引量：5
- 2015年
- 目的探讨DNA甲基化转移酶1/3b(DNMT1/3b)表达异常与肝癌临床病理特征和患者术后生存之间的相关性。方法采用免疫组织化学技术检测89例手术切除肝癌组织中DNMT1和DNMT3b的蛋白表达情况,结合临床病理及无瘤生存期和总生存期,分析DNMT1/3b与临床病理参数、预后的相关性,并通过高通量基因芯片技术筛选肝癌相关DNMT1和DNMT3b的靶基因。结果 89例肝癌组织中DNMT1和DNMT3b皆为阳性63例,皆为阴性5例,单一阳性的分别为9例和12例。DNMT1/3b在肝癌组织中高表达与患者血清AFP(掊2=12.903,P=0.005)、乙型肝炎(掊2=9.535,P=0.023)、卫星灶(掊2=9.574,P=0.023)和肿瘤复发、转移及生存期有关,而与性别、肿瘤大小、肝硬化和肿瘤分化无关;Kaplan-Meier分析显示DNMT1/3b阳性组患者生存时间较阴性组短,差异有统计学意义(P<0.05)。高通量基因组甲基化芯片技术筛选出肝癌细胞中受DNMT1和DNMT3b调控的基因2 000多个,其中参与肿瘤侵袭转移的靶基因有112个。结论 DNMT1/3b在肝癌组织中高表达与患者血清AFP、乙型肝炎、卫星灶和肿瘤复发、转移等临床病理特征和生存期密切相关,并可能通过调控多方面肿瘤相关基因促进肝癌复发、转移等恶性表型。
- 方钦亮谢程融赵文秀孙红光尹毅锐张盛王付强彭友缘王效民尹震宇
- 关键词：肝癌生存期
- Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinoma
- ＜正＞Background Hepatocellular carcinoma（HCC）is a common malignancy worldwide,which is especially prevalent in A...
- 何飞李杰许剑锋张盛许雅苹赵文秀尹震宇王效民
- 文献传递
- Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
- ＜正＞DLCl has been shown to be downregulated or absent in hepatocellular carcinoma（HCC）and is associated with tu...
- 谢程融孙红光孙宇赵文秀张盛王效民尹震宇
- 文献传递
- Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways
- ＜正＞Hepatocellular carcinoma（HCC）progresses rapidly and is frequendy associated with vascular invasion,metastas...
- 赵必星赵文秀王瑜许雅苹许剑锋唐凯张盛尹震宇吴乔王效民
- 文献传递
- Integrated analysis of gene expression and DNA methylation changes induced by hepatocyte growth factor in human hepatocytes
- ＜正＞Hepatocellular carcinoma（HCC）is the one of most common malignant tumors.The tumor microenvironment has a ro...
- 谢程融孙红光王付强李钊尹毅锐方钦亮孙宇赵文秀张盛王效民尹震宇尹震宇
- 文献传递
- Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma
- ＜正＞It has been reported that NKD1 was an antagonist of the canonical Wnt/β-catenin pathway.While there is litd...
- 张盛李杰尹震宇刘平果赵文秀谢程融赵必星王效民
- 文献传递
- Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy
- ＜正＞Cholangiocarcinoma（CCA）,a devastating cancer with a poor prognosis,is resistant to the currently available ...
- 洪再发赵文秀尹震宇谢程融许雅苹池小琴张盛王效民
- 文献传递
- 氯离子通道蛋白1在肝癌中的表达情况及其临床意义
- 目的 研究氯离子通道蛋白1(CLIC1)在肝癌组织中的表达情况及其与肝癌临床病理因素和预后之间的关系.方法 采用蛋白质印迹和实时定量PCR实验分别检测了40对新鲜肝癌组织及其配对的癌旁正常肝组织中的蛋白和mRNA水平.收...
- 张盛刘平果赵文秀尹震宇王效民
- Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poorprognosis
- ＜正＞Pygopus-2（Pygo2）is a critical element of the canonical Wnt/(3-catenin transcriptional complex.The aim of th...
- 张盛李杰何飞王效民
- 文献传递
- Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
- ＜正＞Pygopus-2 over-expression has been reported in several malignancies,such as ovarian,breast,lung and liver c...
- 张盛李杰刘平果许剑锋赵文秀谢程融尹震宇王效民
- 文献传递
