To study the effects of Midazolam in preventing patients under combined anesthesia from awareness and affect for regain consciousness in different time iv. Methods 45 patients under combined anesthesia were divided random equally into three groups: C, D1 and D2. These patients were induced and intubated with Fentanyl, Vercurium, Propofol iv. In group D1 Midazolam iv in the meantime induction, in group De Midazolam iv after induction 30 min, while in gropu C were not iv Midazolam.The anesthetic sum, time from operation and to extubation, awareness and recall were compared with C and D1, D2. Result It is beneficial that to add midazolam in combined anesthesia to avoid awareness and/recall. The effects are different in refrain from awareness and affect for recover), time with the different time iv. Conclusion It is best that midazolam iv in the meantime induction to prevent from awareness, reduce anesthetic sum, shorten the anesthesia recovery time and steady patients condition.