Objective To observe the clinical effect of acupuncture in combination with medicine in the treatment of mild cognitive impairment after cerebral infarction as well as the impact on patients' daily living ability. Methods Seventy-two patients, in accordance with random number table, were divided into two groups, acupuncture combined with western medicine group (group A) and western medicine group (group B), each group with 36 patients. In combination with nimodipine tablets, acupuncture which can regulate the mind and reinforce the intelligence [making Baihui (百会 GV 20), Sishencong (四神聪EX-HN 1), Sibai (四白 ST 2), Fengchi (风池 GB 20), Wanggu (完骨 GB 12), Tianzhu (天柱 BL 10), Shenmen (神门 HT 7), Neiguan (内关 PC 6), Shuigou (水沟 GV 26), Sanyinjiao (三阴交 SP 6), Taichong (太冲 LR 3), Fenglong (丰隆 ST 40) as the main acupoints] was given in the treatment group (group A) while only nimodipine tablets were given in the control group (group B). The efficacy of these two groups was evaluated by Montreal Cognitive Assessment (MoCA) Scale after the continuous treatment for three months. Results The remarkably effective rate was 69.4%.and the total effective rate was 91.7% in the treatment group, while the remarkably effective rate was 55.6% and the total effective rate was 80.6% in the control group; the differences between the two groups were statistically significant (P〈0.05). When comparing the MoCA score before and after treatment, which was 20.23±4.67 before treatment and 26.84±3.87 after treatment in group A; 19.82±3.56 before treatment and 23.33±2.78 after treatment in group B, it was found that the score for both groups became higher after treatment than that before treatment. Furthermore, the increase of the score was higher in the treatment group (6.61±0.80) than that in the control group (3.51±0.78) and the differences were statistically significant (P〈0.05). Conclusion Acupunctu