In order to solve the no-wait flowshop scheduling problem to minimize the maximum lateness,three job-block-based neighborhoods are proposed,among which the block exchange neighborhood have a size of O(n4)while the block swap and the simplified block exchange neighborhoods have a size of O(n3).With larger sizes than the existing neighborhoods,the proposed neighborhoods can enhance the solution quality of local search algorithms.Speedup properties for the neighborhoods are developed,which can evaluate a neighbor in constant time and explore the neighborhoods in time proportional to their proposed sizes. Unlike the dominance-rule-based speedup method,the proposed speedups are applicable to any machine number.Three neighborhoods and the union of block swap and the simplified block exchange neighborhoods are compared in the tabu search.Computational results on benchmark instances show that three tabu search algorithms with O(n3)neighborhoods outperform the existing algorithms and the tabu search algorithm with the union has the best performance among all the tested algorithms.