[Objective] To provide quantification means for comprehensively analyzing the coordinated development of urban human settlement and economy by constructing an index system of economy and human settlement. [Method] By constructing an evaluation index system of economy and human settlement, and using the coordinate measurement model of them, 22 county-level cities in the Yellow River Basin were analyzed. [Result] In the Yellow River Basin, the construction level of economy and human settlement in those county-level cities is low with distinct spatial differences and deteriorating polarization; there is a great spatial corresponding between coordinated development degree and economic level, the higher the economic development level, the higher coordinated development degree in county-level cities; county-level cities around the boundaries of provinces have difficulties in development. [Conclusion] Evaluation standards and models are clear in significance, convenient in application, which can successfully evaluate the coordination of human settlement development in the study region.