Considering the ecological environment of Sichuan area, an experiment was conducted to breed new maize varieties with high yield, high quality, multi re- sistance and wide adaptability. According to the principle of gene recombination, the authors combined the local tropical germplasm with PB germplasm, which was rich in disease-resistant, lodging-resistant and drought-tolerant genes, and the integration was used as the innovative strategy for breeding. Inbred-line 'LSC 107' was suc- cessfully bred and the new maize hybrid 'Wande No.l' was bred by crossing 'LSC 107' with 'Yi 99-19'. The results showed that the maize hybrid had good performance, including high yield, good stability, high quality, excellent disease re- sistance and lodging resistance, and wide adaptation. So it was adaptable for plant- ing in plain and hilly areas of Sichuan Province. With hybrid recombination between local tropical germplasm and PB inbred lines, the inbred-line had high general com- bining ability and strong adaptability, and the hybrid had high yield, high quality and wide adaptability, and had broad prospects of popularization and application.