Objective To investigate clinical therapeutic effects of acupuncture combined with ear point embedding for treating sleep disorder in depression. Methods Seventy-six patients suffering from sleep disorder in depression were randomly divided into an observation group (39 cases) and a control group (37 cases). In observation group, acupuncture at Baihui (百会 GV 20), Shangxing (上星 GV 23), Shenting (神庭 GV 24), Fengchi (风池 GB 20) and Shenmen (神门 HT 7), etc., which was combined with ear point embedding, and in control group, Fluoxetine Hydrochloride Dispersible tablet (Prozac) was orally given. Four weeks of treatments were given as a therapeutic course in both groups. Comparison of changes in scores of HAMD and PSQI was made between the two groups. Results After treatment, HAMD scores were obviously lowered in both groups (both P〈0.01), and the reduction in HAMD score was more obvious in observation group than that in control group (P〈0.05). After treatment, the reduction in PSQI score was more obvious in observation group (P〈0.01), it was more significantly decreased than that in control group. Conclusion Acupuncture combined with ear point embedding provids remarkable therapeutic effects in treating sleep disorder in depression, which is superior to those provided by Fluoxetine Hydrochloride Dispersible Fablet orally given.