Objective To explore effective therapeutic method for the treatment of ocular myasthenia gravis. Methods Sixty cases of ocular myasthenia gravis were selected. The acupuncture was applied at Dàzhuī (大椎 GV 14), Bǎihuì (百会 GV 20), Shàngxīng (上星 GV 23) of Governor Vessel, and its crossing points with Yinqiao and Yangqiao Meridian, such as Jīngmíng (睛明 BL 1), shēnmài (申脉 BL 62), Dìcāng (地仓 ST 4), Jūliáo (巨髎 ST 3), Chéngqì (承泣 ST 1 ), etc. Besides, ginger-partition moxibustion was applied at Yángbái (阳白 GB 14) and Sìbái (四白 ST 2). The plum-blossom needle was applied at upper limb distribution of lung channel of hand taiyin, heart channel of hand shaoyin and pericardium channel of hand jueyin. The patients’ clinical symptoms, potential degradation percentages of repetitive nerve stimulation (RNS) in low frequency were observed. Results 8 cases were clinically cured, 20 cases were basically cured, 12 cases were remarkably effective, 15 cases were effective and 5 cases were failed. The total effective rate was 91.7%. Compared with before the treatment, the potential degradation percentages of repetitive nerve stimulation in low frequency were lowered [(19.44±6.28)% vs (8.78±3.12)%, (P0.05)]. Conclusion Acupuncture and moxibustion at extra-meridian and collateral for ocular myasthenia gravis could achieve positive efficacy.